After the merger that created the Women's Missionary Society (WMS) of the United Lutheran Church in America, a 15-member General Literature Committee was given the responsibility of publishing the society's official publication. The Lutheran Mission Worker, the official publication of the Women's Missionary Society of the General Council joined with Lutheran Woman's Work, the official publication of the Women's Home and Foreign Missionary Society (WHFMS) of the General Synod. The first issue appeared June 1919. The new monthly publication had a combined circulation of 32,000. Its first editor was Margaret R. Seebach, editor of the periodical when it was part of the WHFMS. Two associate editors had been the editors of the mission publications in their respective societies. Mrs. F.A. Kahler of the General Council and Mrs. E.C. Cronk of the United Synod of the South joined with Mrs. Seebach in publishing the new society's magazine. 

The format of the magazine generally followed that of its WHFMS predecessor. There were feature articles pertaining to missions, sections on home and foreign mission work and missionaries, a young woman's page, department bulletins, convention reports, and the monthly program for auxiliaries. The back cover was used for promotional purposes. Over the years, there were format and artwork changes to reflect style changes.  Sections were added, modified, or removed depending on needs. The May 1956 issue was the first to be published under the organization's new name, United Lutheran Church Women (ULCW). The last issue of Lutheran Woman's Work was February 1960. Starting in March 1960, the ULCW joined in a new magazine venture, Lutheran Women, which was produced as an interim publication for the women's groups of the church bodies that would merge to form the Lutheran Church in America in 1962.